Key takeaways

  • Trodelvy is a prescription medication given by IV infusion to treat specific types of breast cancer. The dosage is calculated based on body weight in kilograms (kg).
  • Treatment with Trodelvy involves a 21-day cycle where Trodelvy is given on days 1 and 8.
  • Your doctor may reduce your dose or stop Trodelvy if you experience certain serious side effects or those that are difficult to tolerate.

Trodelvy is a prescription drug used in adults to treat the following cancers in certain situations:

The active ingredient in Trodelvy is sacituzumab govitecan-hziy. Trodelvy belongs to a group of drugs called antibody-drug conjugates. It’s a biologic, which means that it’s made from living cells.

This article describes the dosage of Trodelvy, as well as its strength and how it’s given.

The information below describes the dosage of Trodelvy that’s commonly used or recommended. Your doctor will determine the best dosage to fit your needs.

Trodelvy form

Trodelvy comes as a powder in a single-dose vial. Your doctor or another healthcare professional will prepare Trodelvy by mixing the powder with liquid to make a solution. They’ll give you the drug as an intravenous (IV) infusion (an injection into a vein given over time).

Trodelvy strength

Trodelvy comes in one strength: 180 milligrams (mg).

The dosage of Trodelvy for breast cancer is based on body weight. Your doctor will calculate your dosage using your weight in kg. One kilogram equals about 2.2 pounds (lb).

The recommended dosage for Trodelvy is 10 mg per kg of body weight. This is given on days 1 and 8 of a 21-day treatment cycle. Your doctor will have you repeat this cycle as long as the drug is safe and effective for your condition.

Dosage adjustments and reduction

If you have serious side effects from Trodelvy, your doctor may slow your infusion time. They may also recommend a dose reduction. They’ll ultimately prescribe the smallest dosage that provides the desired effect.

If your side effects are severe or continue after a dose reduction, your doctor may have you permanently stop Trodelvy.

Your doctor will give you Trodelvy as an IV infusion at a clinic, doctor’s office, or hospital.

Before each dose, your healthcare team may give you medications to help prevent side effects from Trodelvy. These side effects include infusion reactions, nausea, and vomiting.

You’ll receive a Trodelvy dose on days 1 and 8 of a 21-day treatment cycle. In other words, you’ll receive a Trodelvy infusion on one day of the first and second weeks of a 3-week cycle. You won’t receive a Trodelvy dose during the third week of the cycle.

The infusion time of your first dose will likely be longer than for doses that follow.

First Trodelvy infusion

Your first Trodelvy infusion will take about 3 hours. Afterward, your doctor will monitor you for at least 30 minutes. They’ll watch for signs of serious side effects from the infusion or the medication.

If you have serious side effects during the infusion, your doctor may slow down or stop the infusion.

Later Trodelvy infusions

If you don’t have severe side effects during your first Trodelvy dose, you’ll receive your next infusions over the course of 1 to 2 hours. As with your first dose, your doctor will monitor you for at least 30 minutes afterward to see whether you experience side effects.

How long do you have Trodelvy treatment?

Trodelvy is usually used as a long-term treatment. How long you receive the drug will be determined by you and your doctor. It will also depend on how your body and cancer respond to treatment.

If your cancer worsens or you have serious side effects from this medication, your doctor may stop Trodelvy treatment.

Disclaimer: Healthline has made every effort to make certain that all information is factually correct, comprehensive, and up to date. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. You should always consult your doctor or another healthcare professional before taking any medication. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses.