Zepbound is most effective when combined with a balanced diet and regular exercise. Eating plenty of filling and nutrient-dense foods can help you work toward your weight loss goals.

Zepbound is FDA approved and prescribed to:

  • reduce excess body weight and maintain weight loss long term in adults with obesity, to be used along with a reduced-calorie diet and increased physical activity
  • reduce excess body weight and maintain weight loss long term in adults with overweight plus at least one weight-related complication, to be used along with a reduced-calorie diet and increased physical activity
  • treat moderate to severe obstructive sleep apnea in adults with obesity

In this article, you can learn about some foods to eat and avoid during treatment with Zepbound.

Zepbound works by decreasing your appetite and reducing your food intake. You don’t need to adhere to a specific diet while taking Zepbound. But keep in mind that you use this medication in combination with a reduced-calorie diet and regular exercise.

For losing weight, most dieticians recommend two key factors in a diet, which are:

  • balanced nutrition
  • lower calorie intake than what you need to maintain your body weight
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Certain eating patterns or diets can help you lose weight and manage weight loss when used along with physical activity. Eating patterns sometimes differ. But the following two diets share several common factors that may work well during Zepbound treatment.

Mediterranean diet

The Mediterranean diet is one of the eating patterns most linked to healthy outcomes. It’s often recommended for weight management. The following table highlights the patterns of this diet:

EmphasizeIncludeLimit
• vegetables
• fruits
• whole grains
• beans and legumes
• low fat or fat-free dairy
• fish
• poultry
• nontropical vegetable oils
• nuts
• added sugars
• sugary beverages
• sodium
• highly processed foods
• refined carbohydrates
• saturated fats
• fatty or processed meats

United States Department of Agriculture (USDA) recommendations

For optimum weight management, the USDA published Dietary Guidelines for Americans 2020–2025. In it, the USDA recommends eating a diet that’s similar to the Mediterranean diet. This table summarizes the USDA recommendations:

EmphasizeMinimizeAvoid
• fruits
• vegetables
• whole grains
• fat-free or low fat milk products

a variety of protein foods such as:
• seafood
• lean meats
• poultry
• eggs
• legumes
• soy products
• nuts and seeds
• saturated fats
• trans fats
• cholesterol
• added sugars
• salt
processed foods with added sugar, such as:
• soda and soft drinks
• candy and chocolates
• pastries and doughnuts
• sweetened cereals
• ice cream and frozen desserts
• flavored yogurt
• fruit drinks and sports drinks
• syrups
• granola bars and protein bars
• sweetened coffee or tea beverages

Processed foods with added sugar usually don’t offer much nutritional benefit. They also can cause your blood sugar to go up and down. Fluctuations in blood sugar can promote fat gain and cause cravings for sugary snacks.

The recommended daily value of protein for adults over the age of 18 years is 0.8 grams (g) per kilogram (kg) of body weight. For reference, 1 kg is about 2.2 pounds (lb). For a person weighing 150 lb, this is at least 54 g of protein daily. For a person weighing 250 lb, this is at least 90 g daily.

While taking Zepbound, no particular amount of protein needs to be consumed. But it’s often recommended to get at least 10% to 35% of your total calories from protein. It’s a good idea to try and reach these minimum amounts to support your overall health.

If your goal is to lose weight, it might be tempting to skip breakfast. But eating breakfast can help keep you feeling full longer. Plus, it may help keep your blood sugar levels stable throughout the day.

A 2023 study included a group of people with overweight or obesity and type 2 diabetes. Its researchers found that consuming breakfast was linked to greater weight loss. People who ate breakfast lost more weight than the people who skipped it.

It’s best to avoid overly sugary foods for breakfast since these may lead to rapid spikes in your blood sugar.

Some breakfast ideas that can help support your weight loss goals are:

  • Greek yogurt with berries and oats
  • avocado toast with an egg
  • sugar-free oatmeal with seeds and berries
  • vegetable omelet
  • smoothie with high protein powder
  • whole grain pancakes with an egg and fresh fruit

Nutrient-rich meals have foods rich in protein and nutrients. These meal ideas can help support your weight loss goals during Zepbound treatment:

BreakfastLunchDinner
• smoothie with protein powder and fresh or frozen fruit
• oatmeal with Greek yogurt, seeds, and fruit
• avocado toast with an egg
• omelet with vegetables
• salmon with brown rice and high fiber vegetables such as spinach or broccoli
• grilled chicken sandwich
• quinoa bowl with beans or chickpeas
• lentil soup with whole grain bread
• salmon poke bowl
• chicken stir-fry with mixed vegetables
• shrimp tacos with slaw
• lentil and vegetable curry
• tofu and vegetable stir-fry
• cauliflower fried rice with fish

No, you don’t have to do anything specific before a Zepbound injection. You can inject Zepbound with or without regard to meals. Eating does not influence the effectiveness of your injection.

Zepbound works by decreasing your appetite. In turn, that can reduce the amount of food you eat.

Some people develop nausea as a side effect of Zepbound. If you do and you’re having difficulty eating, you may want to adjust your meals. Try eating more frequent, smaller meals, focusing on protein and foods rich in nutrients.

If you do have nausea and it’s severe or persistent, it’s a good idea to see your doctor. Your doctor may recommend lowering your dose of Zepbound or stopping the medication.

You don’t need to eat or avoid any particular foods when taking Zepbound. But for best results, you should combine the medication with regular physical activity and a balanced diet.

Eating plenty of nutrient-rich foods such as whole grains, fish, fruits, and vegetables can help support your weight loss goals. It’s a good idea to minimize your intake of highly processed foods that contain added sugar. They don’t offer much nutritional value and aren’t filling.

Some people may experience certain side effects during treatment with Zepbound that prevent them from eating. The side effects may decrease their appetite or make it difficult to eat. If you experience these side effects, let your doctor know. They may lower your dosage or stop the medication.

Disclaimer: Healthline has made every effort to make certain that all information is factually correct, comprehensive, and up to date. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. You should always consult your doctor or another healthcare professional before taking any medication. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses.