Medicare may cover Skyrizi (risankizumab-rzaa) if you have a plan with prescription drug benefits, such as a Part D or Medicare Advantage (Part C) plan.

Skyrizi is a brand-name, biologic drug that doctors may prescribe to treat conditions like psoriasis and psoriatic arthritis.

Skyrizi belongs to a group of drugs called interleukin-23 (IL-23) inhibitors. The Food and Drug Administration (FDA) has approved the drug to treat these conditions:

  • psoriatic arthritis
  • moderate to severe plaque psoriasis
  • Crohn’s disease
  • ulcerative colitis

To receive coverage for Skyrizi, you need to be a Medicare prescription drug plan enrollee.

If you have Original Medicare (parts A and B), you can enroll in a stand-alone Part D plan to cover your medications.

If you have a Medicare Advantage plan, you may have prescription drug coverage as part of your plan. However, not all Medicare Advantage plans include drug benefits.

Private insurance companies offer Medicare drug plans. Their lists of covered drugs differ. Your plan may cover Skyrizi if it’s in the plan’s formulary. Most Part D plans cover Skyrizi.

Review your plan’s documentation or contact a representative to learn whether it covers Skyrizi. If it doesn’t, it may cover an alternative medication.

Medicare offers a coverage finder tool to allow users to find plans in their area that include coverage for Skyrizi.

The amount you pay for Skyrizi may depend on a few factors, including your location and plan and the drug’s tier.

Medicare prescription drug plans group covered drugs into cost tiers. Skyrizi is typically a higher tier drug without a generic version.

According to the drug’s manufacturer, the wholesale acquisition cost of one Skyrizi dose is $22,383.49.

The amount you pay for Skyrizi may also depend on your coverage stage.

Most Part D plans have three stages of coverage. Beneficiaries may have different out-of-pocket expenses depending on the stage:

  • Deductible stage: If your plan has a deductible, you must pay the full medication cost until you reach your deductible amount. In 2025, the maximum deductible amount for a Part D plan is $590.
  • Initial coverage stage: After meeting your deductible, you must pay a 25% coinsurance on covered medications until your out-of-pocket costs reach $2,000.
  • Catastrophic stage: Once you spend $2,000 in a calendar year, you may pay no more for covered medications. In 2026, the out-of-pocket maximum may be $2,100.

Your costs may be lower if you qualify for cost assistance through the Extra Help program.