There’s limited scientific evidence directly linking semaglutide use to vitamin B12 deficiency or recommending routine vitamin B12 supplementation for people taking semaglutide.

Semaglutide is the active ingredient in Ozempic and Rybelsus, and it is used to manage type 2 diabetes and obesity.

Compounded semaglutide with vitamin B12 is available in the market but has not been approved by the Food and Drug Administration (FDA). Some healthcare professionals may recommend the combination because of theoretical considerations.

Semaglutide works by mimicking GLP-1, a hormone that helps control blood sugar levels by causing the pancreas to release insulin, decreasing the production of glucagon, and slowing down the emptying of the stomach.

All GLP-1 receptor agonist drugs, like semaglutide, slow down gastric emptying and reduce stomach acid production. This means they could affect the absorption of vitamin B12, which can potentially lead to vitamin B12 deficiency or worsen it in someone who already has it. Vitamin B12 is absorbed in the stomach with the help of stomach acid and intrinsic factor, a protein produced by the stomach.

In theory, receiving a compounded semaglutide and B12 injection may help prevent vitamin B12 deficiency and could potentially enhance the medication’s therapeutic effects.

However, there is no scientific evidence indicating that semaglutide should be taken with vitamin B12. It is advisable to consult with a healthcare professional to determine if vitamin B12 supplementation is needed based on your needs and risk factors.

Semaglutide has been shown to be effective for weight loss in people with obesity.

In one study, the use of semaglutide over 104 weeks showed significant weight loss benefits for people with obesity or overweight and related health challenges. Those on semaglutide lost an average of 15.2% of their body weight, compared to 2.6% in the placebo group. However, more gastrointestinal side effects were reported with semaglutide.

B12 isn’t typically used as a primary weight loss treatment, but it’s important for overall health and may support the body’s metabolism and energy production, which could potentially complement the weight loss effects of semaglutide. More research is needed to confirm the effects of compounded semaglutide with vitamin B12 for weight loss.

A semaglutide and B12 compounded injection is typically administered as semaglutide without B12 vitamin. it is a subcutaneous shot, meaning it’s injected under the skin. Here’s what you can generally expect from semaglutide treatment:

  • Injection site: The injection is usually given in the abdomen, thigh, or upper arm. A healthcare professional will show you how to properly administer the injection or will do it for you.
  • Frequency: Semaglutide with B12 is usually injected once a week. You typically start with a 0.25 mg dose of semaglutide and B12, and your doctor may adjust the dose to 0.5 mg based on your needs.
  • Weight loss: In a study of 175 participants with overweight or obesity, those taking semaglutide lost 5.9% of their body weight at 3 months and 10.9% at 6 months. For someone weighing 200 pounds, this would be around 11-21 pounds at 3 months and 20-39 pounds at 6 months. Combining it with B12 might enhance these effects.
  • Improved blood sugar management: Semaglutide stimulates insulin production and reduces glucose production, helping to lower blood sugar levels. B12 may further support this process by promoting the proper functioning of insulin-producing cells in the pancreas.
  • Increased energy levels: B12 helps manage the fatigue often experienced with semaglutide therapy, leading to enhanced energy levels and improved well-being.
  • Support for cardiovascular health: B12 helps improve markers of heart health, potentially reducing the risk of heart-related complications in people with type 2 diabetes.
  • Management of side effects: Though side effects of semaglutide are typically mild, including nausea and diarrhea, B12 is being studied as a potential strategy to lessen these effects when compounded with semaglutide.

Semaglutide may lead to gastrointestinal problems, such as nausea, diarrhea, or constipation. These side effects are usually mild and tend to improve over time.

In addition, some people may experience increased hunger if they miss a dose of semaglutide.

Semaglutide treats type 2 diabetes and obesity. It works by mimicking a hormone called GLP-1, which helps regulate blood sugar levels and reduce appetite. Taking compounded semaglutide and vitamin B12 may enhance its effects, as B12 helps maintain energy levels and supports nervous system health. However, this is a theoretical conclusion, and no scientific evidence exists to back this claim.

If you think you might benefit from compounded semaglutide with vitamin B12, consult with a healthcare professional to discuss the potential benefits and risks.